Author: BioProNET Network – Page 2

5th Annual Science Meeting

BioProNET’s flagship Annual Science Meeting will be held on October 10-11th 2018 at British Medical Association House, Central London. We anticipate that a preliminary programme and registration will be available in Spring 2108.

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BBSRC-CASE project with AstraZeneca

Investigating the cutaneous lipidome to understand how skin responds to sunlight exposure

We want to explore the UVR-induced changes in skin lipids as means of understanding the normal physiology of human skin when exposed to sunlight, and appreciate the role of lipids in maintaining skin health. We will then use this information to understand how human skin reacts with xenobiotics that interact with sunlight and, this way, support the design of studies for the development of pharmaceuticals. Overall, the project will allow detailed study and understanding of the skin lipidome and perturbations induced by sunlight and xenobiotics, permit mapping of lipid networks contributing to inflammatory responses and inform research into human health.

We will use 3D human skin models, primary skin cells in culture, and human skin in organ culture. We will then employ mass spectrometry-based assays and lipid imaging to assess changes in the various types of skin lipids and their accumulation in cell membranes.

The project will provide training in multiple disciplines (biochemistry, analytics, pharmaceutics, biology) including the handling of large data sets generated by lipidomics. While at UoM, the student will train in cell and organ culture, lipid extractions and analyses by mass spectrometry (triple quadrupole and time-of-flight coupled to liquid and supercritical fluid chromatography), and data processing. During the placement periods, the student will learn the requirements of drug development and how skin physiology and photo reactivity can inform drug discovery. The student will also have access to AstraZeneca’s research into microphysiological systems and 3D cell models that will be used to investigate aspects of normal skin functioning, and will work with AstraZeneca’s world leading mass spectrometry imaging group to investigate novel ways to detect changes in the lipidome.

This is a CASE studentship is to be funded under the BBSRC Doctoral Training Programme. If you are interested in this project, please make direct contact with the Principal Supervisor to arrange to discuss the project further as soon as possible. You MUST also submit an online application form – full details on how to apply can be found on the BBSRC DTP website.

https://www.research.manchester.ac.uk/portal/anna.nicolaou.html
https://www.findaphd.com/search/ProjectDetails.aspx?PJID=90077&LID=1020
https://www.bmh.manchester.ac.uk/study/research/bbsrc-dtp/

Faculty position – University of Delaware

The Department of Chemical & Biomolecular Engineering at the
University of Delaware invites applications for a tenure-track open rank
Professor position.

REQUIREMENTS: Ph.D. or equivalent in chemical engineering or a related field.

DUTIES: The Department of Chemical & Biomolecular Engineering seeks faculty
candidates to develop and lead a vigorous and nationally recognized research
program; teach and advise students at both the undergraduate and graduate levels;
and participate in and contribute to the departmental and larger professional
community. While applications in all research areas will be considered, we particularly
seek applicants with expertise in biopharmaceutical manufacturing, bioinformatics,
and systems design and optimization, especially those that synergize with the new
manufacturing excellence centers, NIIMBL and RAPID.

APPLICATION: Please submit a curriculum vitae, a description of research and
teaching interests, and the names, addresses, telephone numbers and email addresses
of at least 3 references at apply.interfolio.com/44338. Applications will be considered
until the position is filled. The curriculum vitae and letters of recommendation will be
shared with department faculty.

Jobs at AstraZeneca / MedImmune

AstraZeneca and MedImmune have several roles available:

New – added to BioProNET site on October 16th:

https://astrazeneca.wd3.myworkdayjobs.com/MedImmune-Careers/job/UK—Liverpool/Analytical-Development-associate–AS-II—-Virology_R-014811-1

https://astrazeneca.wd3.myworkdayjobs.com/MedImmune-Careers/job/UK—Liverpool/Analytical-Development-scientist–Sci-I-_R-014809

https://astrazeneca.wd3.myworkdayjobs.com/MedImmune-Careers/job/UK—Liverpool/QC-Technical-Support-Manager_R-015661

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Analytical Development (AS I/II) (Liverpool)
https://astrazeneca.wd3.myworkdayjobs.com/broadbean_external/job/UK—Liverpool/Analytical-Development-scientist–AS-I-II-_R-013819-2

Engineering Business Process Specialist (Liverpool)
https://astrazeneca.wd3.myworkdayjobs.com/MedImmune-Careers/job/UK—Liverpool/Engineering-Business-Process-Specialist_R-012073

Cell Culture and Bioreactor Process Development: Associate Scientist II (Cambridge)
https://astrazeneca.wd3.myworkdayjobs.com/MedImmune-Careers/job/UK—Cambridge/Cell-Culture-and-Bioreactor-Process-Development–Associate-Scientist-II_R-012735-1

Cell Culture and Bioreactor Process Development Scientist (Sci I) (Cambridge)
https://astrazeneca.wd3.myworkdayjobs.com/MedImmune-Careers/job/UK—Cambridge/Cell-Culture-and-Bioreactor-Process-Development-Scientist–Sci-I-_R-008712

Bioreactor Scientist (AS II / SCI I) (Cambridge)
https://astrazeneca.wd3.myworkdayjobs.com/MedImmune-Careers/job/UK—Cambridge/Bioreactor-Scientist–AS-II—SCI-I-_R-008101

 

Several vacancies at F-star

F-star develops therapeutic bi-specific antibodies using its Modular Antibody Technology, directed at improving the treatment of serious diseases, with a focus on immune-oncology. We are entering an exciting period of the Company’s development and have several vacancies at the Babraham Research Campus in Cambridge, UK.

Research associate – protein sciences
You will be responsible for protein purification and subsequent routine characterisation, filtrations and sterility testing of antigens, antibody fragments and bi-specific mAb2 molecules.
• A relevant degree and/or a combination of education and experience
• Good track record of relevant hands-on, lab-based experience
• Protein purification using AKTA system (antibody purification, ion exchange, affinity chromatography; eg IMAC)
• Protein characterisation (HPLC, SDS-PAGE, endotoxin level testing etc.)
• Relevant industry experience

Research associate – molecular biology
You will be responsible for the design and execution of expression vector cloning to express antibodies and fusion proteins in mammalian systems
• Relevant experience ideally gained in an industrial environment
• Hands-on experience in molecular biology techniques and vector design for expression of antibodies in mammalian systems (DNA manipulation, cloning, sequence alignment and analysis)
• Knowledge in antibody engineering (eg isotype/subtype reformatting)

Research associate – mammalian cell culture
You will be responsible for transient and stable expression of recombinant proteins in mammalian cell lines at several lab scales.
• Relevant industry or academic experience in mammalian cell culture
• Hands-on experience in transient expression of recombinant proteins using mammalian cell systems (HEK293 and CHO)
• Knowledge in CHO cell line development including transfection, marker selection and generation of stable pools will be an advantage

Scientist – protein characterisation
you will proactively contribute to the development and delivery of analytical capabilities to support our technology platform and mAb2 bispecific pipeline.  Analytical capabilities are required to deliver protein engineering, research grade production and process development activities with a key focus on protein characterisation, developability assessments and formulation
– PhD or equivalent relevant experience, ideally gained in an industrial environment although consideration will be given to industrially relevant academic experience
– Experience and breadth of knowledge in analytical and biophysical characterisation of recombinant biotherapeutics for CMC development. (e.g. formulation, protein aggregation, protein stability and post-translational modifications including glycosylation)
– Experience in early stage developability assessment of therapeutic proteins and development lifecycle for recombinant protein therapeutics
– Demonstrated experience in establishing and applying the following techniques: dynamic and static light scattering, capillary electrophoresis, SVP, UHPLC (SEC, RP, IEX), mass spectrometry

Further details of these and other exciting roles along with instructions how to apply can be found at http://www.f-star.com/careers