Author: BioProNET Network – Page 2

IBSCA funding awarded

BioProNET has recently awarded six indistrial biotecnology seeding catalyst awards (IBSCA). This funding aims to develop and progress ideas and technology within the scope and remit of BioProNET and the call along the technology readiness level (TRL) pathway.

Pilot production of engineered nucleases with applications in molecular biology and diagnostic devices
Jon Sayers, University of Sheffield

Optimization of influenza vaccine manufacturing through inhibition of autophagy
Jeremy Rossman, University of Kent

Improved microfluidic devices for downstream bioprocess separation of sub-micron targets
Alan Goddard, Aston University

Learning from charge interactions in nature to understand poly-anion/cation complementarity in drug encapsulation
Jim Warwicker, University of Manchester

Engineering secretory capacity in S. cerevisiae strains to improve recombinant protein production yield
Campbell Gourley, University of Kent

Enhancing secretory pathway function to allow selection of host cell clones
Lisa Swanton, University of Manchester

Establishing a prototype process for manufacturing non‐therapeutic biologics expressed in plants for the R&D market
Anil Day, University of Manchester

5th Annual Science Meeting

BioProNET’s flagship Annual Science Meeting will be held on October 10-11th 2018 at British Medical Association House, Central London. We anticipate that a preliminary programme and registration will be available in Spring 2108.

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Faculty position – University of Delaware

The Department of Chemical & Biomolecular Engineering at the
University of Delaware invites applications for a tenure-track open rank
Professor position.

REQUIREMENTS: Ph.D. or equivalent in chemical engineering or a related field.

DUTIES: The Department of Chemical & Biomolecular Engineering seeks faculty
candidates to develop and lead a vigorous and nationally recognized research
program; teach and advise students at both the undergraduate and graduate levels;
and participate in and contribute to the departmental and larger professional
community. While applications in all research areas will be considered, we particularly
seek applicants with expertise in biopharmaceutical manufacturing, bioinformatics,
and systems design and optimization, especially those that synergize with the new
manufacturing excellence centers, NIIMBL and RAPID.

APPLICATION: Please submit a curriculum vitae, a description of research and
teaching interests, and the names, addresses, telephone numbers and email addresses
of at least 3 references at apply.interfolio.com/44338. Applications will be considered
until the position is filled. The curriculum vitae and letters of recommendation will be
shared with department faculty.

Jobs at AstraZeneca / MedImmune

AstraZeneca and MedImmune have several roles available:

New – added to BioProNET site on October 16th:

https://astrazeneca.wd3.myworkdayjobs.com/MedImmune-Careers/job/UK—Liverpool/Analytical-Development-associate–AS-II—-Virology_R-014811-1

https://astrazeneca.wd3.myworkdayjobs.com/MedImmune-Careers/job/UK—Liverpool/Analytical-Development-scientist–Sci-I-_R-014809

https://astrazeneca.wd3.myworkdayjobs.com/MedImmune-Careers/job/UK—Liverpool/QC-Technical-Support-Manager_R-015661

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Analytical Development (AS I/II) (Liverpool)
https://astrazeneca.wd3.myworkdayjobs.com/broadbean_external/job/UK—Liverpool/Analytical-Development-scientist–AS-I-II-_R-013819-2

Engineering Business Process Specialist (Liverpool)
https://astrazeneca.wd3.myworkdayjobs.com/MedImmune-Careers/job/UK—Liverpool/Engineering-Business-Process-Specialist_R-012073

Cell Culture and Bioreactor Process Development: Associate Scientist II (Cambridge)
https://astrazeneca.wd3.myworkdayjobs.com/MedImmune-Careers/job/UK—Cambridge/Cell-Culture-and-Bioreactor-Process-Development–Associate-Scientist-II_R-012735-1

Cell Culture and Bioreactor Process Development Scientist (Sci I) (Cambridge)
https://astrazeneca.wd3.myworkdayjobs.com/MedImmune-Careers/job/UK—Cambridge/Cell-Culture-and-Bioreactor-Process-Development-Scientist–Sci-I-_R-008712

Bioreactor Scientist (AS II / SCI I) (Cambridge)
https://astrazeneca.wd3.myworkdayjobs.com/MedImmune-Careers/job/UK—Cambridge/Bioreactor-Scientist–AS-II—SCI-I-_R-008101

 

Several vacancies at F-star

F-star develops therapeutic bi-specific antibodies using its Modular Antibody Technology, directed at improving the treatment of serious diseases, with a focus on immune-oncology. We are entering an exciting period of the Company’s development and have several vacancies at the Babraham Research Campus in Cambridge, UK.

Research associate – protein sciences
You will be responsible for protein purification and subsequent routine characterisation, filtrations and sterility testing of antigens, antibody fragments and bi-specific mAb2 molecules.
• A relevant degree and/or a combination of education and experience
• Good track record of relevant hands-on, lab-based experience
• Protein purification using AKTA system (antibody purification, ion exchange, affinity chromatography; eg IMAC)
• Protein characterisation (HPLC, SDS-PAGE, endotoxin level testing etc.)
• Relevant industry experience

Research associate – molecular biology
You will be responsible for the design and execution of expression vector cloning to express antibodies and fusion proteins in mammalian systems
• Relevant experience ideally gained in an industrial environment
• Hands-on experience in molecular biology techniques and vector design for expression of antibodies in mammalian systems (DNA manipulation, cloning, sequence alignment and analysis)
• Knowledge in antibody engineering (eg isotype/subtype reformatting)

Research associate – mammalian cell culture
You will be responsible for transient and stable expression of recombinant proteins in mammalian cell lines at several lab scales.
• Relevant industry or academic experience in mammalian cell culture
• Hands-on experience in transient expression of recombinant proteins using mammalian cell systems (HEK293 and CHO)
• Knowledge in CHO cell line development including transfection, marker selection and generation of stable pools will be an advantage

Scientist – protein characterisation
you will proactively contribute to the development and delivery of analytical capabilities to support our technology platform and mAb2 bispecific pipeline.  Analytical capabilities are required to deliver protein engineering, research grade production and process development activities with a key focus on protein characterisation, developability assessments and formulation
– PhD or equivalent relevant experience, ideally gained in an industrial environment although consideration will be given to industrially relevant academic experience
– Experience and breadth of knowledge in analytical and biophysical characterisation of recombinant biotherapeutics for CMC development. (e.g. formulation, protein aggregation, protein stability and post-translational modifications including glycosylation)
– Experience in early stage developability assessment of therapeutic proteins and development lifecycle for recombinant protein therapeutics
– Demonstrated experience in establishing and applying the following techniques: dynamic and static light scattering, capillary electrophoresis, SVP, UHPLC (SEC, RP, IEX), mass spectrometry

Further details of these and other exciting roles along with instructions how to apply can be found at http://www.f-star.com/careers