Outcomes of IBSCA funding

BioProNET recently funded 7 Industrial Biotechnology Seeding Catalyst Award. These awards were designed to accelerate translational research by developing and progressing research along the technology readiness level (TRL) pathway, increasing business—academic engagement and company leverage on innovation activities, as well as generating data to support applications for larger grant funding. Below are the key aims and outcomes from each of these projects.

Download a pdf here

STARS School 2018: Embedding the Industrial Perspective

BBSRC Strategic Training Awards for Research Skills (STARS) School 2018: Embedding the Industrial Perspective

For Early Career Researchers: The Bioprocessing Skills School

Do you want to find out how your career might develop working for industry, the differences between industrial- and academic-driven research and how the industrial environment matches your career ambitions?  Here’s your opportunity to answer these questions and find out much more about your ability to work in teams and how the innovative, entrepreneurial spirit drives research translation.

At our week-long, intensive residential training programme, designed around the insights and advice of senior industrialists, you will take part in group-based activities and work with real-life industrial case studies. The programme is designed to engage with the process of entrepreneurship, focus on the development of the ability to promote research ideas and their value to audiences and the key importance of the societal impact of industrial biotechnology.

Are you interested? If you are (a) an Early Career Researcher (normally undergoing PhD training or on first Post-doctoral positioning in an academic environment but potentially in the early stages of an industrial career), (b) working in the area of bioprocessing of biopharmaceuticals or novel biological therapeutics (c) on a project that has an industrial collaborator then this could be an ideal opportunity for you.

The week-long residential programme is funded by the BBSRC (accommodation, meals and all training activities) to eligible applicants but will be limited to no more than 18 participants each year.  Each participant will be asked to make a £150 non-returnable contribution for registration once their acceptance of a place is confirmed. Informal enquiries can be made to Dr Jo Flannelly (joanne.flannelly@manchester.ac.uk).

The programme will be held on 9th-14th September 2018, inclusive, at the National Biologics Manufacturing Centre (NBMC, Centre for Process Innovation, CPI, Darlington) and the week will start with a delegate networking dinner on the evening of Sunday 9th at the hotel.

The BioProcessing Skills School has been developed by the Universities of Manchester and Kent, in collaboration with the NBMC and BioProNET, and is funded by the BBSRC Strategic Training Awards for Research Skills (STARS).

Details of the full programme will follow and the sessions will include: molecular design and development of biological therapeutics, generating the tools for self awareness, industrial-scale manufacturing process, drug formulation and delivery embedded within a series of industrial site visits and presentations from industrial practitioners and entrepreneurs.

Register here: https://www.surveymonkey.co.uk/r/STARS_2018_Registration

Current vacancies at F-star

F-star is a biopharmaceutical company focused on developing immuno-oncology bispecific antibody therapeutics. We are poised to dominate the bispecific antibody space in immuno-oncology through the application of our highly efficient Modular Antibody Technology platform. Our powerful platform enables the discovery of novel bispecific antibodies, which are selected for their potential to transform the treatment of cancer. The strength of the technology and programmes has been leveraged through partnerships with leading biopharmaceutical companies including: AbbVie, Bristol-Myers Squibb, Merck KGaA and Denali Therapeutics. F-star’s management team has a well-established track record in building successful biotech companies, and developing biologics. F-star currently employs over 90 people at its research site in Cambridge, UK.

F-star seeks high performing, talented and ambitious individuals. You will join a strong, dynamic and culturally diverse team of experienced scientific leaders. We are located on the attractive Babraham Research Campus near Cambridge, in state of the art laboratories, offering a working environment that fosters creativity, innovation, leadership and teamwork.

All our current vacancies are listed below:

Associate Scientist – Preclinical Translational Pharmacology
Research Associate – Drug Discovery
Scientist – Drug Discovery
Associate Scientist/Scientist – Protein Sciences
Scientist – Preclinical Translational Pharmacology
Research Associate – Preclinical Translational Pharmacology

and coming soon:
CMC Project Manager – Protein Sciences
Principal Scientist – Translational Development

Further details and how to apply can be found here: http://www.f-star.com/careers/

PhD: Development of New Vaccine Manufacturing Platforms

Biological based medicines (e.g. vaccines, recombinant protein based drugs) have provided us with the ability to prevent, treat and cure a multitude of both communicable (infectious diseases) and non-communicable (non-infectious) diseases globally. This project will work with our GCRF partners in Thailand to develop new cell based (bacteria and mammalian cells) vaccine manufacturing platforms for the low cost, rapid development of animal and human vaccines. The objectives will be to use cell engineering and CRISPR/Cas9 genome scanning and editing approaches to identify targets that impact on vaccine production using model Vero, HEK, and as an alternative, Chinese hamster ovary (CHO), cell expression systems and then manipulate the target genes that show positive impact on viral vaccine production to generate stably engineered novel hosts for expression of viral and bacterial vaccines.

For further information please contact Prof Mark Smales Applications will be considered until the deadline of 18th May, 2018. Interviews will be held at the Kent site in the week of 21st May, 2018.

More details: https://www.findaphd.com/search/ProjectDetails.aspx?PJID=97153
To apply please go to https://www.kent.ac.uk/courses/postgraduate/229/biochemistry

 

5th Annual Science Meeting

October 10-11th 2018
British Medical Association House, Central London
Come and join the bioprocessing community at our 5th Annual Science meeting. We anticipate that the meeting will begin at 10.15am on 10th October and finish at 3pm on 11th October.

Registration is open!
https://www.surveymonkey.co.uk/r/BioProNET2018meeting

“The 2017 meeting was one of the most interesting and educational that I have attended in a while!”

Dates
Early April – registration opens
July 6th – registration closes for places with accommodation
July 6th – deadline for short talk abstracts
September 28th – registration closes for day delegates (sooner if capacity is reached)

Sessions
Designing more efficient cell-expression systems
Molecular characterisation of process quality
Building expression systems into optimised process
The clinic and beyond
Upstream meets downstream – rapid process development

Confirmed speakers
Kerstin Otte
– University of Applied Science Biberach, Germany Identification and characterisation of intracellular production bottlenecks in CHO cells producing complex biopharmaceuticals
Colin Robinson – University of Kent Development of next generation E. coli platforms for the regulated production and periplasmic targeting of biotherapeutics 
Nathan Lewis – University of California San Diego, USA Engineering CHO cells with enhanced traits with multiplex genome editing
Gary FinkaGlaxoSmithKline Developing a next-generation cell line development platform through targeted automation, analytics and informatics
Tarit Mukhopadhyay University College London Manufacturing the future at less than a $1 a dose and meeting global health needs
Caroline Barelle Elasmogen soloMERä Biologics: Site-specific therapeutic biologics for the treatment of inflammatory disease
Phil Cater Leaf Expression Systems Plant produced biologics – process economics
Paul Dalby University College London New analytical methods for chromatography OR further downstream to formulation.
Yvonne Genzel Max Planck Institute for Dynamics of Complex Technical Systems, Germany Intensified cell-based viral vaccine processes: from continuous to perfusion and to hybrid systems.
Chris van der Walle MedImmune Manufacture and characterisation of nanoparticles encapsulating nucleic acids
Pernille Harris – Technical University of Denmark Solution structure and self-association of pharmaceutical proteins
Jonathan BonesThe National Institute for Bioprocessing Research and Training, Ireland Characterisation of biopharmaceuticals using intact protein separations hyphenated to high resolution native mass spectrometry
Laura Palomares – National Autonomous University of Mexico Challenges of bringing recombinant vaccines to the market: A case study for a influenza vaccine
Mike Betenbaugh – Johns Hopkins University, USA Glycoengineering of mammalian cell lines to improve product quality

Proof of Concept funding awardees
Dave Brockwell University of Leeds Investigating the effects of hydrodynamic force on the structure and biological integrity of a viral vector gene therapy product
Michael Plevin University of York Can an archaeal helicase enhance the performance of a nanopore DNA sequencer?
Gary Montague Teesside University Improved preservation of biologics by continuous intensified lyophilisation

We will also invite early career researchers to give short talks – more details on the registration form.

Registration is open!
https://www.surveymonkey.co.uk/r/BioProNET2018meeting

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