Category: Success Stories

Outcomes of IBSCA funding

BioProNET recently funded 7 Industrial Biotechnology Seeding Catalyst Award. These awards were designed to accelerate translational research by developing and progressing research along the technology readiness level (TRL) pathway, increasing business—academic engagement and company leverage on innovation activities, as well as generating data to support applications for larger grant funding. Below are the key aims and outcomes from each of these projects.

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Funding secured after BioProNET projects

To date, BioProNET-funded projects have leveraged over £990,000 of funding from industry to support collaborative bioprocessing projects.

Below are details of funding that has been secured following on from, or as a result of a BioProNET-funded project.

PhD: Microbial biotechnology applications for the production of novel enzymes’, lab work (of £10k per year) supported by Johnson Matthey following on from a business interaction voucher (BIV_Feb18_Dikicioglu) awarded to Duygu Dikicioglu

Algal vaccines for Aquaculture
Funded Value: £160,399 Funder: BBSRC
Saul Purton and Brenda Parker, University College London, following on from BIV_May17_Purton

Innovate UK funding of £70K for the project ‘Development of a novel membrane photobioreactor for cultivation of Haematococcus pluvialis as a biofilm’ to Varicon Aqua Solutions (following from BIV_Aug15_Allen)

Funding of £681K from the BBSRC and the US NSF for the project ‘synthetic gene circuits to measure and mitigate translational stress during heterologous protein expression’ to Ian Stanfield (following on from the BioProNET sandpit meeting).

Funding of £1.5M from the EPSRC awarded to Paul Dalby et al. for the project ‘Enabling rapid liquid and freeze-dried formulation design for the manufacture and delivery of novel biopharmaceuticals’ (from PoC_Dec14_Warwicker).

Publications from BioProNET funding

Escherichia coli ‘TatExpress’ strains export several g/L human growth hormone to periplasm by the Tat pathway Guerrero Montero, I., Robinson, C. et al. Biotech. Bioeng. (2019 in press).

Web-based display of protein surface and pH-dependent properties for assessing the developability of biotherapeutics Hebditch M and Warwicker J. Scientific Reports 9, 1969 (2019

Characterization of a novel method for the production of single-span membrane proteins in Escherichia coli Smith SM, Walker KL, Jones AS, Smith CJ, Robinson C. Biotechnol Bioeng. 116, 722-733 (2019) doi: 10.1002/bit.26895

Hybrid mass spectrometry methods reveal lot-to-lot differences and delineate the effects of glycosylation on the tertiary structure of Herceptin Rosie Upton, Perdita Barran et al. Chem. Sci., 2019, doi: 10.1039/C8SC05029E

Surface patches on recombinant erythropoietin predict protein solubility: engineering proteins to minimise aggregation M. Alejandro Carballo-Amador, Jim Warwicker et al. BMC Biotechnology 19, 26 (2019)

Biosensor-assisted engineering of a high-yield Pichia pastoris cell-free protein synthesis platform Rochelle Aw and Karen Polizzi Biotechnol Bioeng.116, 656­–666 (2019) doi: 10.1002/bit.26901

A protein chimera strategy supports production of a model difficult-to-express recombinant target Hirra Hussain, James Winterburn et al.FEBS Letters 592, 2499–2511 (2018)

Tailoring the performance of organic solvent nanofiltration membranes with biophenol coatings Fan Fei, Gyorgy Szekely et al. ACS Appl. Polym. Mater. 1 452–460 (2019)

Constrained global sensitivity analysis for bioprocess design space identification
Pavlos Kotidisa, Cleo Kontoravdi et al. Computers & Chemical Engineering 125, 558-568 (2019)

Integrated production and separation of biosurfactants Ben Dolman, Fuju Wang & James Winterburn. Process Biochemistry 83,1-8 (2019)

New perspectives on protein aggregation during biopharmaceutical development
Maryam Shah International Journal of Pharmaceutics 552, 1-6 (2018)

A protein chimera strategy supports production of a model difficult-to-express recombinant target Hirra Hussain, Alan Dickson et al. FEBS Letters592 2499–2511 (2018)

In vitro model for predicting bioavailability of subcutaneously injected monoclonal antibodies
Hanne Kinnunen Bown, Catherine Bonn, Stefan Yohe, Daniela Bumbaca Yadav, Thomas Patapoff, Ann Daugherty, Randall Mrsny
Journal of Controlled Release, Volume 273, Pages 13-20 10.1016/j.jconrel.2018.01.015

Case studies of BioProNET-funded projects

Here are some highlights of completed BioProNET-funded projects – proof of concept funding, business interaction vouchers, workshop funding and scientific exchange awards.

Clicking on each title will open a pdf version of that case study. To see all the case studies in full on this website, click on the purple bar below the titles.

A new top-down mass spectrometry method for the rapid analysis of biopharmaceuticals
Analysis of historical bioprocessing data gives clues to microbial culture performance
Scale-up of vaccine production in a microalgal host for animal trials
Cobra Biologics – an interview with Daniel Smith
BioProNET early career researchers get more business acumen!
Molecular imprinting for sustainable downstream processing of biopharmaceuticals
Assessing the production of diagnostic proteins in plant cell cultures
An express route to biopharmaceutical production
A machine learning poly-omics classifier to improve protein production in CHO cells
Scientific exchange visit boosts separation technologies collaboration
Speeding up and slowing down: altering translation speed to enhance protein yield
Hijacking intracellular storage bodies to produce difficult to express proteins
Developing a novel fluorescence-based biopharmaceutical quality control technology
Design & testing of a membrane
for advanced biologic production
Collaborative development of glycolipid separation technology to reduce costs
BioProNET funding drives the use of motor proteins for nanopore DNA sequencing
BIV funding grows algae bioprocessing collaboration
BIV funding lights up collaboration on fluorescent protein expression in microalgae
PoC study shows protein synthesis errors can cause activity losses in recombinant protein
Warwick and JEOL Strike Gold in Electron Microscopy Collaboration
Dynamic partnership aims to reduce cell harvest time
Cobra and Lancaster partnership helps unravel new analytical tool for DNA topology
Collaboration creates a recipe for success in cell-free protein synthesis
Edinburgh and Recyclatech Join Forces to Recover Microbial By-Products
Sandpit Meeting Builds Collaboration Workshop
Exchange visit funding seeds early career researcher collaborations
Scissor technology cuts out a collaboration between Bath and Arecor