Publications from BioProNET funding

Escherichia coli ‘TatExpress’ strains export several g/L human growth hormone to periplasm by the Tat pathway Guerrero Montero, I., Robinson, C. et al. Biotech. Bioeng. (2019 in press).

Web-based display of protein surface and pH-dependent properties for assessing the developability of biotherapeutics Hebditch M and Warwicker J. Scientific Reports 9, 1969 (2019

Characterization of a novel method for the production of single-span membrane proteins in Escherichia coli Smith SM, Walker KL, Jones AS, Smith CJ, Robinson C. Biotechnol Bioeng. 116, 722-733 (2019) doi: 10.1002/bit.26895

Hybrid mass spectrometry methods reveal lot-to-lot differences and delineate the effects of glycosylation on the tertiary structure of Herceptin Rosie Upton, Perdita Barran et al. Chem. Sci., 2019, doi: 10.1039/C8SC05029E

Surface patches on recombinant erythropoietin predict protein solubility: engineering proteins to minimise aggregation M. Alejandro Carballo-Amador, Jim Warwicker et al. BMC Biotechnology 19, 26 (2019)

Biosensor-assisted engineering of a high-yield Pichia pastoris cell-free protein synthesis platform Rochelle Aw and Karen Polizzi Biotechnol Bioeng.116, 656­–666 (2019) doi: 10.1002/bit.26901

A protein chimera strategy supports production of a model difficult-to-express recombinant target Hirra Hussain, James Winterburn et al.FEBS Letters 592, 2499–2511 (2018)

Tailoring the performance of organic solvent nanofiltration membranes with biophenol coatings Fan Fei, Gyorgy Szekely et al. ACS Appl. Polym. Mater. 1 452–460 (2019)

Constrained global sensitivity analysis for bioprocess design space identification
Pavlos Kotidisa, Cleo Kontoravdi et al. Computers & Chemical Engineering 125, 558-568 (2019)

Integrated production and separation of biosurfactants Ben Dolman, Fuju Wang & James Winterburn. Process Biochemistry 83,1-8 (2019)

New perspectives on protein aggregation during biopharmaceutical development
Maryam Shah International Journal of Pharmaceutics 552, 1-6 (2018)

A protein chimera strategy supports production of a model difficult-to-express recombinant target Hirra Hussain, Alan Dickson et al. FEBS Letters592 2499–2511 (2018)

In vitro model for predicting bioavailability of subcutaneously injected monoclonal antibodies
Hanne Kinnunen Bown, Catherine Bonn, Stefan Yohe, Daniela Bumbaca Yadav, Thomas Patapoff, Ann Daugherty, Randall Mrsny
Journal of Controlled Release, Volume 273, Pages 13-20 10.1016/j.jconrel.2018.01.015

Codon-depedent translational accuracy controls protein quality in Eschericha coli but not Saccharomyces cerevisiae
Lyne Jossé, Connor D. D. Sampson, Mick F. Tuite, Kevin Howland,Tobias von der Haar
doi: (preprint)

TatA complexes exhibit a marked change in organisation in response to expression of the TatBC complex
Sarah M. Smith, Andrew Yarwood, Roland A. Fleck, Colin Robinson, and Corinne J. Smith
Biochem J. 474, 1495–1508, 2017

Protein-Sol: A web tool for predicting protein solubility from sequence
Hebditch M, Alejandro Carballo-Amador M, Charonis S, Curtis R, Warwicker J.
Bioinformatics doi: 10.1093/bioinformatics/btx345 May 29 2017

A poly-omics machine-learning method to predict metabolite production in CHO cells
Zampieri, G., Coggins, M., Valle, G. and Angione, C. Proceedings of the The 2nd International Electronic Conference on Metabolomics, 20–27 November 2017; doi:10.3390/iecm-2-04993

Long-term stability and reusability of molecularly imprinted polymers
Jozsef Kupai, Mayamin Razali, Sibel Buyuktiryaki, Rustem Kecili and Gyorgy Szekely
Polym. Chem., 8, 666-673 (2017) DOI: 10.1039/C6PY01853J

Exploring and exploiting the effect of solvent treatment in membrane separations
Mayamin Razali, Christos Didaskalou, Jeong F. Kim, Masoud Babaei, Enrico Drioli, Young Moo Lee, and Gyorgy Szekely
ACS Appl. Mater. Interfaces, 9, 11279–11289 (2017) DOI: 10.1021/acsami.7b01879

Valorisation of agricultural waste with an adsorption/nanofiltration hybrid process: from materials to sustainable process design
Christos Didaskalou, Sibel Buyuktiryaki, Rustem Kecili, Claudio P. Fonte and Gyorgy Szekely
Green Chem., 19, 3116-3125 (2017) DOI: 10.1039/C7GC00912G

A cell culture platform for cryptosporidium that tnables long-term cultivation and new tools for the systematic investigation of its biology
Christopher N. Miller, Lyne Josse, Ian R. Brown, Ben Blakeman, Jane Povey, Lyto Yiangou, Mark Price, Jindrich Cinatl Jr., Wei-Feng Xue, Martin Michaelis, Anastasios Tsaousis
doi: (preprint)

Robust covalently cross-linked polybenzimidazole/graphene oxide membranes for high-flux organic solvent nanofiltration
Fan Fei, Levente Cseri, Gyorgy Szekely and Christopher F. Blanford
ACS Appl. Mater. Interfaces, 2018, 10 16140–16147 DOI: 10.1021/acsami.8b03591

Patent application GB1604640.1 published as WO2017158371A1
University of Bath
Method and apparatus