Category: Jobs

PDRA position: downsized cell-derived peptides as potent inhibitors of alpha-synuclein toxicity

Dr Jody Mason’s lab at the University of Bath is looking for a bright and enthusiastic individual who is interested in using a new and cutting edge peptide library screening approach to derive functional peptide-based antagonists of alpha-Synuclein (aS) associated toxicity. The project is wide-ranging and will involve extensive molecular biology, peptide synthesis, and protein biochemistry to derive functional antagonists and to characterise their mechanism of action (see Cheruvara et al., J Biol Chem 2015). The project is highly collaborative and will be undertaken in collaboration with partners at Bath and the University of Queensland to provide a detailed picture of how antagonists function, including their ability to block aS associated toxicity both in vitro and within live neuronal cells, The project will require travel in the UK and possibly beyond.

PDRA position: functionally active peptide inhibitors of transcription factor activity

Dr Jody Mason’s lab at the University of Bath is looking for a bright and enthusiastic individual who is interested in using a new and cutting edge peptide library screening approach to derive functional peptide-based antagonists of transcription factor activity. The project is wide-ranging and will involve extensive molecular biology, peptide synthesis, and protein biochemistry to derive functional antagonists and to characterise their mechanism of action (see Baxter et al. ACS Chem Biol, 2017). The project is highly collaborative and will be undertaken in collaboration with partners in the UK and the University of Queensland to provide a detailed picture of how antagonists function, including their ability to block transcription of target genes, The project will require travel in the UK and possibly beyond.

PDRA position: functionally active peptide inhibitors of transcription factor activity

Dr Neil Kad’s lab at the University of Kent is looking for a bright and enthusiastic individual who is interested in using state-of-the-art single molecule techniques to image transcription factor interactions with DNA tightropes (see Kad et al., 2010). The project is wide-ranging from protein biochemistry to single molecule data collection and analysis. This project will be undertaken in collaboration with partners and will require travel in the UK and possibly beyond.

Peak Proteins – senior/principal scientist in protein engineering, expression & purification

We are now looking for a senior or principal scientist in protein engineering, expression and purification. We expect the successful candidate to be able to confidently devise and adapt project plans in consultation with clients, to efficiently manage projects as they progress both as a result of their own experimental skills and by working closely together with other scientists within Peak Proteins and in the client organisations. This role provides a great opportunity for someone to have a major impact on the science, business and growth of a small and dynamic company.

Current vacancies at F-star

F-star is a biopharmaceutical company focused on developing immuno-oncology bispecific antibody therapeutics. We are poised to dominate the bispecific antibody space in immuno-oncology through the application of our highly efficient Modular Antibody Technology platform. Our powerful platform enables the discovery of novel bispecific antibodies, which are selected for their potential to transform the treatment of cancer. The strength of the technology and programmes has been leveraged through partnerships with leading biopharmaceutical companies including: AbbVie, Bristol-Myers Squibb, Merck KGaA and Denali Therapeutics. F-star’s management team has a well-established track record in building successful biotech companies, and developing biologics. F-star currently employs over 90 people at its research site in Cambridge, UK.

F-star seeks high performing, talented and ambitious individuals. You will join a strong, dynamic and culturally diverse team of experienced scientific leaders. We are located on the attractive Babraham Research Campus near Cambridge, in state of the art laboratories, offering a working environment that fosters creativity, innovation, leadership and teamwork.

All our current vacancies are listed below:

Associate Scientist – Preclinical Translational Pharmacology
Research Associate – Drug Discovery
Scientist – Drug Discovery
Associate Scientist/Scientist – Protein Sciences
Scientist – Preclinical Translational Pharmacology
Research Associate – Preclinical Translational Pharmacology

and coming soon:
CMC Project Manager – Protein Sciences
Principal Scientist – Translational Development

Further details and how to apply can be found here: http://www.f-star.com/careers/