Author: biopronet

BioProNET is ending – stay in touch

BioProNET was granted a no-cost extension by the BBSRC to run until the end of August 2019. We have been investigating mechanisms by which to sustain the network beyond August 2019, and in particular to hold a Science Meeting in 2020.

Due to data protection rules, we are not allowed to use our BioProNET mailing list once funding for the network has finished.

Thank you for clicking on the link in an email that was sent to you indicate that you would like to stay in touch and be kept informed of a future bioprocessing network. Your preference has been noted.

If you arrived at this page not through an email link but would like to stay in touch please contact Charlotte c.harrison-560@kent.ac.uk

Vacancies at Cobra Biologics

Senior Scientist, Downstream Processing: Innovation, Keele (Ref:CBK1719)

The successful candidate will be responsible for biologics (multiple product type) downstream processing development.

  • Contribution to the design and planning of processes with accountability for leading the execution of assigned process development, client transfer or internal Research and Development programmes of work.
  • Supporting the transfer of processes into GMP across all sites or to external clients.
  • Responsibility for the interpretation of data, impact assessment and provision of recommendations for further development or scale up.
  • Supporting commercial activities and working closely with Project Management.
  • Supporting Cobra’s Research and Development programme including poster presentations and conference attendance where applicable.

Experienced GMP Microbial Fermentation Scientist, Keele, Staffordshire (Ref:CBK1619)

A vacancy has arisen for an Experienced GMP Microbial Fermentation Scientist to work within Product Delivery.

  • Execution of Microbial Fermentation and Microbial Cell Banking within the GMP cleanroom facility.
  • To maintain the status of the GMP production facility clean rooms.
  • Compliant execution of GMP processes in a timely manner according to Manufacturing Plans and Batch Manufacturing Records.
  • Ensure laboratory notebooks and Batch Manufacturing Records are completed and maintained according to Cobra Standard Operating Procedures.
  • Update Standard Operating Procedures and Material Specification Sheets as required.
  • To form part of multidisciplinary teams, lead by the Production Manager or Senior Scientist, taking processes from the client/development/technology transfer stage into GMP.

GMP Mammalian & Virus Scientist, Keele, Staffordshire (Ref:CBK1519)

Vacancies have arisen for a GMP Scientist and an Experienced GMP Scientist within the Cell Culture and Virus Production Team to work within Product Delivery.

  • Execution of cell culture and virus production within the GMP Clean Room facility.
  • To maintain the status of the GMP production facility clean rooms.
  • Compliant execution of GMP processes in a timely manner according to Manufacturing Plans and Batch Manufacturing Records.
  • Ensure laboratory notebooks and/or Batch Manufacturing Records are completed and maintained according to Cobra Standard Operating Procedures.
  • Update Standard Operating Procedures and Material Specification Sheets as required.
  • To form part of multidisciplinary teams, lead by the Production Manager or Senior Scientist, taking processes from the client/development/technology transfer stage into GMP.

Senior Scientist, Technology and Bioanalysis: Innovation, Keele, (Ref:CBK1819)

The successful candidate will be responsible for driving analytical development and technology transfer activities for DNA and viral vector manufacture.

  • Development and execution of a range of analytical assays for biomolecule characterisation.
  • Mammalian cell culture and transient transfection, relating to viral vector production.
  • Supporting the transfer of processes into GMP across all sites or to external clients.
  • Responsibility for the interpretation of data, impact assessment and provision of recommendations for further development or scale up.
  • Supporting Commercial activities and working closely with Project Management.

Senior Scientist, Technology and Bioanalysis: Innovation, Keele, (Ref:CBK1919)

The successful candidate will be responsible for the optimisation of viral vector bioprocessing and analytical characterisation.

  • Mammalian cell culture and transient transfection, relating to viral vector production.
  • Viral vector bioprocessing using mammalian cell culture, including some experience in upstream and downstream methodologies.
  • Supporting the transfer of processes into GMP across all sites or to external clients.
  • Responsibility for the interpretation of data, impact assessment and provision of recommendations for further development or scale up.
  • Supporting Commercial activities and working closely with Project Management.

Scientist, Upstream Processing: Innovation, Keele, (Ref:CBK2119)

The successful candidate will be responsible for biologics upstream process development.

  • Execution of microbial fermentation (shake flask and bioreactor) and microbial cell banking within our research and high quality facilities in support of commercial contracts, gene therapy viral vector development and Innovate UK grants with academic institutions.
  • To assist in the transfer/development of new processes, unit operations or techniques within the team and into GMP across all sites or to external clients.
  • Interpretation of data, communicating results and performing impact assessment.
  • Generate study plans, technical reports, Standard Operating Procedures and Batch Reports as required.

More details on these posts at www.cobrabio.com/jobs

6th Annual Science Meeting

The Principal Hotel, Manchester
June 3-4th 2019

Our flagship science meeting this year reflected on the science that has been developed to date through BioProNET support, and also provide a forward vision of the science that will underpin the next 10 years of bioprocessing.

10.00 Registration
The Cell Factory: Proteins are go

co-chaired by Emma Hargreaves and Mark Smales

11.00 Nicole Borth, University of Natural Resources and Life Sciences (BOKU), Vienna – CHO genome news: variation, phenotypes and control
11.30 Tobias von der Haar, University of Kent – Controlling bioprocessing parameters through efficient sequence design
11.45 Sarah Smith, University of Warwick – Exploiting electron microscopy to optimise protein and biologic expression systems
12.00 Anil Day, University of Manchester – A high-yield expression platform for manufacturing recombinant human growth factors
12.15 Jose Guterriez-Marcos, University of Warwick – Rapid production of high value biologics in plant cell cultures
12.30 Poster talks: Gizem Buldum, Imperial College London – Monitoring the effect of accessory proteins on a CHO-based cell-free protein synthesis factory

Théo Mozzanino, University of Kent – Engineering the CHO secretory pathway for enhanced secretory recombinant protein production

12.40 Douglas Browning, University of Birmingham – Playing a round with recombinant protein production: what is PAR for the course
12.55 Lunch
The Cell Factory: Nucleic acids are go    chaired by Nicole Borth
14.00 Uta Griesenbach, Imperial College London – Latest developments in cystic fibrosis gene therapy
14.30 Michael Plevin, University of York – DNA motor proteins for nanopore sequencing
14:45 Duygu Dikicioglu, University of Cambridge – Addressing challenges in pre-processing and mining bioprocess development data in biocatalyst manufacturing by machine learning
15.00 Lorna Ashton, Lancaster University – Raman spectroscopy and gene therapy
15.15 Poster talks: George Prout, Cobra Biologics – Optimisation of a scalable rAAV production process 

Zoltán Kis, Imperial College London – Techno-economic analysis of emerging vaccine platform and production technologies 

15:25 James Budge, University of Kent – Engineering of CHO cell lipid metabolism to enhance biotherapeutic protein production
15.40 Refreshment break, networking, posters
Beyond the Cell and into Manufacturing          chaired by Gary Lye
16.10 Nigel Robinson, Durham University – Protein metalation in Industrial Biotechnology: E3B BBSRC NIBB opportunities
16.40 Jon Sayers, University of Sheffield – Engineering nucleases for genetic engineering and diagnostic applications
16.55 Gary Montague, Teesside University – Improved preservation of biologics by continuous intensified lyophilisation
17.10 Hirra Hussain & Louis Darton, Universities of Manchester and Kent – The BBSRC-funded Strategic Training Awards for Research Skills (STARS): The Bioprocessing Training Programme
17.25 Mark Carver, Bio-Industry Association SIAC – Shaping the future: where next for bio-processing research?
17.55 Hotel check-in
18.20 Poster session and drinks reception
20.00 Conference dinner

Day 2 – 4thJune

New Approaches and Enabling Technologies        chaired by Paul Dalby
8.45 Paul Kellam, Kymab – Deep mining of antibody responses – picking your best therapeutic mAb or vaccine
9.15 James Winterburn, University of Manchester – Enhanced glycolipid production and separation: from bench to business with UKRI funding
9.30 Alan Goddard, Aston University – Separation of sub-micron biologicals using microfluidic devices
9.45 Mark Wass, University of Kent – In silico analysis of host cell protein impurities in antibody purification
10.00 Jim Warwicker, University of Manchester – Computational approaches to study biopharmaceutical stability and formulation
10.15 Poster talks: Cloé Legrand, University of Cambridge – MRI characterisation of a microscale parallel bioreactor 

Guido Zampieri, Teesside University – Combining machine learning and metabolic modelling as a tool for bioprocess development

10.25 David Brockwell, University of Leeds – Assessing biopharmaceutical aggregation in vivo and in vitro
10.55 Refreshment break, networking, posters
The Future Should Not Be Unexpected         chaired by Alan Dickson
11.25 Damian Marshall, Cell and Gene Therapy Catapult – Cell and gene therapy manufacture: the emerging role for AI
11.55 Ray Field, AdaptImmune – Bioprocessing for autologous T cell therapy
12.25 Poster talks: Denis Calnan, Thermo Fisher Scientific – A high resolution accurate mass multi-attribute method for critical quality attribute monitoring & new peak detection

Vera Lukashchuk, Cobra Biologics – Development of analytical package for AAV vectors: focus on qPCR 

Tim Eyes, University of Manchester – GeneORator: Smart DNA library design to accelerate the identification of improved protein variants

12.40 Peter Levison, Pall Biotech – Operating in a changing landscape: future process development strategies
13.10 Prize presentation – Colin Miles, BBSRC
13.15 Lunch and meeting close

 

Formulation solutions for diversifying biopharmaceutical portfolios

11 July 2019, Manchester

The next BFG meeting will address the diversification of the products within the biopharmaceutical portfolio, and how fundamental science and understanding developed by the UK formulation community is directing towards effective and predictive solutions for formulation of new biologics and therapeutic formats. The meeting will feature a selection of speakers who represent the many facets of the modern formulation sector from the biopharma field and beyond.

1-2-1 Partnering
There will be an opportunity through partnering software to set up 1-2-1 meetings on the day at various networking times, to maximise opportunities for interaction and future collaborations. We hope that you can make the most of this and please do engage and accept meetings where possible.

Call for posters
There will be a chance for researchers to present posters. Please note your interest on registration and use the free text box to indicate title and short descriptor. Deadline for your expression of interest is the 26th June 2019.

Early career bursaries
If you are an early career scientist (student or first three years of post-doc or industry) and wish to be considered for a bursary to support travel and accommodation, please note this at registration. Bursary recipients are required to present a poster (deadline 26th June 2019).

Registration deadline is 3rd July 2019. More details here.

 

UK–China Interdisciplinary Workshop for Early Career Researchers: Promoting Social Embeddedness of New Biotechnologies

CALL FOR PARTICIPANTS

Beijing, China 14-16 October, 2019

China is the UK’s key partner and co-funder in the biosciences. Collaborative projects with China have substantially shaped policy and professional norms in the research and application of biotechnologies. Yet a number of empirical studies have highlighted that a lack of public engagement in China, together with limited knowledge of Chinese scientific culture, have often cast a shadow on the perceived public accountability towards research carried out in, and with, China. This interdisciplinary workshop, jointly funded by the Newton Fund and the National Natural Science Foundation of China, will bring together 40 funded participants (20 from each country). It will empower a new generation of bioscientists and social scientists from both China and the UK to critically and creatively examine what effective public engagement entails and cultivate a sense of mutual understanding and camaraderie in shaping future governance of the biosciences. In particular, through interactive activities and knowledge sharing, this workshop is focused on delivering the following three aims:

Aim 1: To empower early career professionals in both the biosciences and related areas (e.g. PE, science policy and scientific journalism) with confidence and key skills to actively shape, respond and steer public dialogues of biosciences in an age of intensified transnational exchanges.

Aim 2: To create an interdisciplinary research community for early career researchers to develop practical, effective and socially engaged bioscience based projects.

Aim 3: To co-develop action-plans at both institutional and cross-institutional (including transnational) level to incentivise, facilitate and support effective public engagement of the biosciences.

The workshop is coordinated by Dr. Joy Zhang (University of Kent) and Prof. Xian-En Zhang (Chinese Academy of Sciences, former Director General of Basic Research in China), with major contributions from Prof. Mark Smales (University of Kent), Director Paul Manners (National Co-ordinating Centre for Public Engagement, UK), Prof. Lu Gao (Chinese Academy of Sciences) and Prof. Honglin Li (China Research Institute of Science Popularization).

This is an invitation for bioscience or relevant social science researchers based in the UK who are within 10 years of receiving their PhD (or with equivalent work experience) to apply to participate in this workshop. All travel (including visa), accommodation and meal expenses will be covered by the Newton Fund Researcher Links programme. Travel and medical insurance are not covered by the British Council.

Application and Deadline: UK-based applicants need to submit the following 2 documents to: ukchinaworkshop@kent.ac.uk by 16 June 2019.

  1. A one-page CV (including name, contact details, institutional affiliation, field of expertise, and length of work experience)
  2. A short statement on how you will contribute to the discussion and what you see as the challenges in securing public trust in and/or facilitating social uptake of new biosciences (300-word max).

Notification of results:  Applicants will be notified on the outcome of their application by e-mail by 1 July 2019.