Category: Events – Page 2

3rd Annual Scientific Symposium

October 19–20th 2016, East Midlands Conference Centre

Thank you to everyone who attended our 3rd annual science meeting and contributed to its success. A pdf of the conference booklet is available here.

Congratulations to our prize-winners:
Poster prize first place: Tim Eyes (University of Manchester)
Poster prize second place: Ilokugbe Ettah (Lancaster University)
Poster prize third place: Ben Dolman (University of Manchester)
Early career talk prize: Sarah Hedberg (Imperial College London), pictured below

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Day 1

11.20   Welcome
11.30   Keynote speaker William Barton (Virginia Commonwealth University, USA) Over-expression of secreted proteins from mammalian cell lines
12.15   Lunch

Designing efficient cell-expression systems
Chaired by Pete Tessier
13.00   Robert Roth (AstraZeneca, Sweden) Using phenotypic screening to identify regulators of recombinant protein expression
13.25   Mikael Rørdam Anderson (Technical University of Denmark) Networks: The key to understanding and engineering CHO protein secretion
13.50   Neil Bullied (University of Glasgow) Optimising the design and production of therapeutic antibodies
14.15   Short presentations from BioProNET funding awardees:
Talk 1 – Tim Ganderton (University of York) Hijacking intracellular storage bodies to create a novel mammalian cell-based expression system for the production of hard-to-express proteins
Talk 2 – Stefani Dritsa (University of Kent) Analysis of host cell protein impurities using in silico approaches
14.30   Coffee and networking

Building expression systems into optimised processes
Chaired by Robert Roth
15.15   Kathya de la Luz (Centre of Molecular immunology, Cuba) Linking the cell metabolism and recombinant protein expression in mammalian cell lines: CIM Experiences.
15.40   Colin Jaques (Lonza) Scale-up in the single use age: design matters
16.05   Veronique Chotteau (Institute of Technology Stockholm, Sweden) High cell-density perfusion for biopharmaceutical production – challenges for tomorrow’s processes

16.30   Short presentations from early career researchers (7 minutes each)
Tulshi Patel (University of Kent)
Alfred Fernández-Castané (University of Birmingham)
Claire Bryant (University of Sheffield)
Sarah Hedberg (Imperial College London)
Claire Gaffney (University of Manchester)
Rochelle Aw (Imperial College London)
17.20   Break – hotel check-in and networking

18.00   Poster session (drinks reception, prizes for best posters)
19.30   Dinner, with guest speaker Hansjörg Hauser, Helmholtz Centre for Infection Research, Germany

Day 2

9.00 Keynote speaker – Pete Tessier (Rensselaer Polytechnic Instistute, USA) Improved antibody design, evolution and selection methods for minimizing developability issues

Molecular characterization of process quality
Chaired by
Jurgen Hubbuch
 9.45   JJ Phillips (University of Cambridge) Engineering the surface properties of a human monoclonal antibody prevents self-association and rapid clearance in vivo
10.10   Mike Davies (F-Star) Overcoming the manufacturing challenges for bi-specific mAbs
10.35   Lucy Beales (Mologic) Overcoming development challenges in the development of VLP-based vaccines
11.00 Coffee and networking

Upstream meets downstream: an integrated vision
Chaired by Mikael Rørdam Anderson
11.30   Dan Bracewell (University College London) Nanofibres in bioprocessing: a single-use chromatography format by the use of rapid cycling
11.55   Jurgen Hubbuch (Karlsruhe Institute of Technology, Germany)
12.20   Tim Dafforn (University of Birmingham) Nanoencapsulation for the production of membrane- and periplasmic-trafficked proteins
12.45   Prize giving and meeting close

 

2016 early career researcher event

BioProNET early career research event 2016
September 6–7th Brighton Mercure Seafront Hotel

Many thanks to everyone wh made this year’s event a sucess!

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The programme for this year’s event reflected feedback from delegates at last year’s highly successful meeting; delegates said they wanted more time to focus on CVs, cover letters, being interviewed (and interviewing) and preparation for job applications, as well as presentation skills. The facilitators and presenters at this year’s event had considerable experience of recruiting for bioprocessing- and indistrial biotechnology-related careers.

We were pleased to welcome Martin Popplewell and his team from Coconut Communications to this event to deliver the media training sessions. Martin has more than 25 years of experience working in journalism, including at the BBC, Sky News and ITN.

In the media training session, delegated worked in small groups (6 people) with a trainer in a practical session where they prepared for an interview, were interviewed and then received a personal review and critic of their performance.  They will have two interviews, allowing them to learn and improve, and they received receive a copy of their interviews and a booklet covering the theory of good media interviews.

Day 1 Tuesday 6th September: Presentation and media skills
13.00 Arrival and lunch
14.00 Introduction and interactive group activity
14.30 Presentation and media training part one – Coconut Communications
15.30 Coffee break
15.30 Presentation and media training part two – Coconut Communications
17.30 Social session – Brighton pier and funfair
20.00 Dinner in hotel

Day 2 Wednesday 7th September: CV, interview and interviewing skills*
9.00 Keynote speaker and activities – Tony Bradshaw, Knowledge Transfer Network
10.00 Parallel sessions 1. CV clinic, interview and interviewing in small groups with facilitator
11.15 Coffee break
11.45 Parallel sessions 2. Expert talks – recruiting, CVs and interviews plus Q&A sessions
13.00 Lunch
14.00 Departure

Facilitators
Paul Stephens – UCB
Amanda Weiss – Fujifilm Diosynth Biotechnologies
Paul Davis – Mologic
Andrew Staphnill – University of Cardiff
Mark Smales – University of Kent
Alan Dickson – University of Manchester
Tony Bradshaw – Knowledge Transfer Network
Jamie Parkin – BBSRC
James Winterburn – University of Manchester

 

 

Overcoming Cellular Barriers: Implications for Industrial Biotechnology

Many thanks to everyone who attended this event; we hope that you found it useful and informative. A total of nine new project ideas were identified at the meeting, together with champions to take them forward. If you attanded the meeting and need further information on the projects and/or champions, please contact Charlotte

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July 6th and 7th 2016, Birmingham Hilton Metropole

The function of membranes in bacterial, yeast and mammalian cell factories are an important but underappreciated parameter in optimizing recombinant protein quality and yields.  In addition, the delivery of a therapeutic protein to its target often requires that protein to cross one or more membranes.

Three BBSRC NIBB — BioCatNet, BioProNET and CBMNet — are hosting a two day event to address the challenges of protein secretion and targeting in industrial biotechnology.  Three themes form the backdrop of the meeting: Protein trafficking in eukaryotic cells, protein export from bacterial cell factories and delivery of therapeutic proteins to targets.

The meeting will identify how UK academic and industrial strengths can be exploited to enhance application to future challenges, by combining presentations from leading academics and industrialists to inform and stimulate facilitated discussions. The overall aim is to identify collaborative research projects and teams to bid for funding.

To register, please click here.

Wednesday 6th July, 2016
10.30 Registration
11.00 Welcome, Objectives and Funding available – Me profiles Network Directors
Session 1: Protein Trafficking in Eukaryotic Cells
11.15 How UCB are beginning to address protein trafficking both  in-house and with external collaborators Bernie Sweeney – UCB
11.30 Obtaining a molecular understanding of antibody secretion Andrew Peden – University of Sheffield
Session 2: Protein Export from Bacterial Cell Factories
11.45 Project ‘PeriTune’ -Periplasmic export in e. coli Cobra Biologics
12.00 The Tat pathway as a biotechnological tool for the expression and export of heterologous proteins in E. coli Kelly Walker – University of Kent
Session 3: Delivering Therapeutic Proteins and other compounds substrates/drug molecules 
12.15 Engineering therapeutic proteins for cell entry: the natural approach Ron Jackson, MedImmune
12.30 Engineering biomimetic polymers for intracellular protein delivery Rongjun Chen – Imperial College London
12.45 Review of presentations and scene-setting for discussions to follow
13.00 Lunch and networking
14.00 Parallel Discussions 1
Protein Trafficking Protein Export from Bacterial Cell Factories Delivering Therapeutic Proteins and other molecules
15.25 Report from 3 discussion sessions; definition of topics of interest; themes to be expanded for further development of projects in groups
16.05 Coffee and check-in
16.45 Parallel Discussions 2
Protein Trafficking Protein Export from Bacterial Cell Factories Delivering Therapeutic Proteins and other molecules
17.45 Groups to define initial project areas to develop and for participants to identify their interests for further involvement in day 2 project pitching
18.00 Close
18.30 Networking drinks
19.30 Dinner

 

Thursday 7th July, 2016
09.00 Technology Drivers
09.00 Imaging vesicle transport in cells Gero Steinberg – University of Exeter
09.25 Molecular interactions in membranes and applications of solid state NMR Boyan Bonev – University of Nottingham
09.50 Q & A
10.00 Project Pitching Projects identified at end of day 1 – on pin boards; champion for each gives 5 minute pitch. Formalise interested parties and refine groups for discussions post-coffee break
10.45 Coffee
11.00 Break out Discussion Sessions within project groups
12.30 All Groups reconvene and share ideas – finalise groupings of individuals to carry planning on to next stage
13.00 Lunch
14.00 BIV writing session – on-the-spot applications
15.00 Close