3rd Annual Scientific Symposium

October 19–20th 2016, East Midlands Conference Centre

Thank you to everyone who attended our 3rd annual science meeting and contributed to its success. A pdf of the conference booklet is available here.

Congratulations to our prize-winners:
Poster prize first place: Tim Eyes (University of Manchester)
Poster prize second place: Ilokugbe Ettah (Lancaster University)
Poster prize third place: Ben Dolman (University of Manchester)
Early career talk prize: Sarah Hedberg (Imperial College London), pictured below



Day 1

11.20   Welcome
11.30   Keynote speaker William Barton (Virginia Commonwealth University, USA) Over-expression of secreted proteins from mammalian cell lines
12.15   Lunch

Designing efficient cell-expression systems
Chaired by Pete Tessier
13.00   Robert Roth (AstraZeneca, Sweden) Using phenotypic screening to identify regulators of recombinant protein expression
13.25   Mikael Rørdam Anderson (Technical University of Denmark) Networks: The key to understanding and engineering CHO protein secretion
13.50   Neil Bullied (University of Glasgow) Optimising the design and production of therapeutic antibodies
14.15   Short presentations from BioProNET funding awardees:
Talk 1 – Tim Ganderton (University of York) Hijacking intracellular storage bodies to create a novel mammalian cell-based expression system for the production of hard-to-express proteins
Talk 2 – Stefani Dritsa (University of Kent) Analysis of host cell protein impurities using in silico approaches
14.30   Coffee and networking

Building expression systems into optimised processes
Chaired by Robert Roth
15.15   Kathya de la Luz (Centre of Molecular immunology, Cuba) Linking the cell metabolism and recombinant protein expression in mammalian cell lines: CIM Experiences.
15.40   Colin Jaques (Lonza) Scale-up in the single use age: design matters
16.05   Veronique Chotteau (Institute of Technology Stockholm, Sweden) High cell-density perfusion for biopharmaceutical production – challenges for tomorrow’s processes

16.30   Short presentations from early career researchers (7 minutes each)
Tulshi Patel (University of Kent)
Alfred Fernández-Castané (University of Birmingham)
Claire Bryant (University of Sheffield)
Sarah Hedberg (Imperial College London)
Claire Gaffney (University of Manchester)
Rochelle Aw (Imperial College London)
17.20   Break – hotel check-in and networking

18.00   Poster session (drinks reception, prizes for best posters)
19.30   Dinner, with guest speaker Hansjörg Hauser, Helmholtz Centre for Infection Research, Germany

Day 2

9.00 Keynote speaker – Pete Tessier (Rensselaer Polytechnic Instistute, USA) Improved antibody design, evolution and selection methods for minimizing developability issues

Molecular characterization of process quality
Chaired by
Jurgen Hubbuch
 9.45   JJ Phillips (University of Cambridge) Engineering the surface properties of a human monoclonal antibody prevents self-association and rapid clearance in vivo
10.10   Mike Davies (F-Star) Overcoming the manufacturing challenges for bi-specific mAbs
10.35   Lucy Beales (Mologic) Overcoming development challenges in the development of VLP-based vaccines
11.00 Coffee and networking

Upstream meets downstream: an integrated vision
Chaired by Mikael Rørdam Anderson
11.30   Dan Bracewell (University College London) Nanofibres in bioprocessing: a single-use chromatography format by the use of rapid cycling
11.55   Jurgen Hubbuch (Karlsruhe Institute of Technology, Germany)
12.20   Tim Dafforn (University of Birmingham) Nanoencapsulation for the production of membrane- and periplasmic-trafficked proteins
12.45   Prize giving and meeting close