6th Annual Science Meeting

The Principal Hotel, Manchester
June 3-4th 2019

Our flagship science meeting this year reflected on the science that has been developed to date through BioProNET support, and also provide a forward vision of the science that will underpin the next 10 years of bioprocessing.

10.00 Registration
The Cell Factory: Proteins are go

co-chaired by Emma Hargreaves and Mark Smales

11.00 Nicole Borth, University of Natural Resources and Life Sciences (BOKU), Vienna – CHO genome news: variation, phenotypes and control
11.30 Tobias von der Haar, University of Kent – Controlling bioprocessing parameters through efficient sequence design
11.45 Sarah Smith, University of Warwick – Exploiting electron microscopy to optimise protein and biologic expression systems
12.00 Anil Day, University of Manchester – A high-yield expression platform for manufacturing recombinant human growth factors
12.15 Jose Guterriez-Marcos, University of Warwick – Rapid production of high value biologics in plant cell cultures
12.30 Poster talks: Gizem Buldum, Imperial College London – Monitoring the effect of accessory proteins on a CHO-based cell-free protein synthesis factory

Théo Mozzanino, University of Kent – Engineering the CHO secretory pathway for enhanced secretory recombinant protein production

12.40 Douglas Browning, University of Birmingham – Playing a round with recombinant protein production: what is PAR for the course
12.55 Lunch
The Cell Factory: Nucleic acids are go    chaired by Nicole Borth
14.00 Uta Griesenbach, Imperial College London – Latest developments in cystic fibrosis gene therapy
14.30 Michael Plevin, University of York – DNA motor proteins for nanopore sequencing
14:45 Duygu Dikicioglu, University of Cambridge – Addressing challenges in pre-processing and mining bioprocess development data in biocatalyst manufacturing by machine learning
15.00 Lorna Ashton, Lancaster University – Raman spectroscopy and gene therapy
15.15 Poster talks: George Prout, Cobra Biologics – Optimisation of a scalable rAAV production process 

Zoltán Kis, Imperial College London – Techno-economic analysis of emerging vaccine platform and production technologies 

15:25 James Budge, University of Kent – Engineering of CHO cell lipid metabolism to enhance biotherapeutic protein production
15.40 Refreshment break, networking, posters
Beyond the Cell and into Manufacturing          chaired by Gary Lye
16.10 Nigel Robinson, Durham University – Protein metalation in Industrial Biotechnology: E3B BBSRC NIBB opportunities
16.40 Jon Sayers, University of Sheffield – Engineering nucleases for genetic engineering and diagnostic applications
16.55 Gary Montague, Teesside University – Improved preservation of biologics by continuous intensified lyophilisation
17.10 Hirra Hussain & Louis Darton, Universities of Manchester and Kent – The BBSRC-funded Strategic Training Awards for Research Skills (STARS): The Bioprocessing Training Programme
17.25 Mark Carver, Bio-Industry Association SIAC – Shaping the future: where next for bio-processing research?
17.55 Hotel check-in
18.20 Poster session and drinks reception
20.00 Conference dinner

Day 2 – 4thJune

New Approaches and Enabling Technologies        chaired by Paul Dalby
8.45 Paul Kellam, Kymab – Deep mining of antibody responses – picking your best therapeutic mAb or vaccine
9.15 James Winterburn, University of Manchester – Enhanced glycolipid production and separation: from bench to business with UKRI funding
9.30 Alan Goddard, Aston University – Separation of sub-micron biologicals using microfluidic devices
9.45 Mark Wass, University of Kent – In silico analysis of host cell protein impurities in antibody purification
10.00 Jim Warwicker, University of Manchester – Computational approaches to study biopharmaceutical stability and formulation
10.15 Poster talks: Cloé Legrand, University of Cambridge – MRI characterisation of a microscale parallel bioreactor 

Guido Zampieri, Teesside University – Combining machine learning and metabolic modelling as a tool for bioprocess development

10.25 David Brockwell, University of Leeds – Assessing biopharmaceutical aggregation in vivo and in vitro
10.55 Refreshment break, networking, posters
The Future Should Not Be Unexpected         chaired by Alan Dickson
11.25 Damian Marshall, Cell and Gene Therapy Catapult – Cell and gene therapy manufacture: the emerging role for AI
11.55 Ray Field, AdaptImmune – Bioprocessing for autologous T cell therapy
12.25 Poster talks: Denis Calnan, Thermo Fisher Scientific – A high resolution accurate mass multi-attribute method for critical quality attribute monitoring & new peak detection

Vera Lukashchuk, Cobra Biologics – Development of analytical package for AAV vectors: focus on qPCR 

Tim Eyes, University of Manchester – GeneORator: Smart DNA library design to accelerate the identification of improved protein variants

12.40 Peter Levison, Pall Biotech – Operating in a changing landscape: future process development strategies
13.10 Prize presentation – Colin Miles, BBSRC
13.15 Lunch and meeting close