Several vacancies at F-star

F-star develops therapeutic bi-specific antibodies using its Modular Antibody Technology, directed at improving the treatment of serious diseases, with a focus on immune-oncology. We are entering an exciting period of the Company’s development and have several vacancies at the Babraham Research Campus in Cambridge, UK.

Research associate – protein sciences
You will be responsible for protein purification and subsequent routine characterisation, filtrations and sterility testing of antigens, antibody fragments and bi-specific mAb2 molecules.
• A relevant degree and/or a combination of education and experience
• Good track record of relevant hands-on, lab-based experience
• Protein purification using AKTA system (antibody purification, ion exchange, affinity chromatography; eg IMAC)
• Protein characterisation (HPLC, SDS-PAGE, endotoxin level testing etc.)
• Relevant industry experience

Research associate – molecular biology
You will be responsible for the design and execution of expression vector cloning to express antibodies and fusion proteins in mammalian systems
• Relevant experience ideally gained in an industrial environment
• Hands-on experience in molecular biology techniques and vector design for expression of antibodies in mammalian systems (DNA manipulation, cloning, sequence alignment and analysis)
• Knowledge in antibody engineering (eg isotype/subtype reformatting)

Research associate – mammalian cell culture
You will be responsible for transient and stable expression of recombinant proteins in mammalian cell lines at several lab scales.
• Relevant industry or academic experience in mammalian cell culture
• Hands-on experience in transient expression of recombinant proteins using mammalian cell systems (HEK293 and CHO)
• Knowledge in CHO cell line development including transfection, marker selection and generation of stable pools will be an advantage

Scientist – protein characterisation
you will proactively contribute to the development and delivery of analytical capabilities to support our technology platform and mAb2 bispecific pipeline.  Analytical capabilities are required to deliver protein engineering, research grade production and process development activities with a key focus on protein characterisation, developability assessments and formulation
– PhD or equivalent relevant experience, ideally gained in an industrial environment although consideration will be given to industrially relevant academic experience
– Experience and breadth of knowledge in analytical and biophysical characterisation of recombinant biotherapeutics for CMC development. (e.g. formulation, protein aggregation, protein stability and post-translational modifications including glycosylation)
– Experience in early stage developability assessment of therapeutic proteins and development lifecycle for recombinant protein therapeutics
– Demonstrated experience in establishing and applying the following techniques: dynamic and static light scattering, capillary electrophoresis, SVP, UHPLC (SEC, RP, IEX), mass spectrometry

Further details of these and other exciting roles along with instructions how to apply can be found at http://www.f-star.com/careers